The P9 Protein: A Microbial Signal to the Gut In mouse and cell studies, researchers found that Akkermansia secretes a protein called P9, which binds to a receptor (ICAM-2) on gut cells and triggers GLP-1 release, and in mice it also raised energy expenditure (Yoon et al., 2021)
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Chronic stress elevates cortisol levels, which can slow digestive motility, alter gut microbiome composition, and increase intestinal permeability